Bio-therapeutics Laboratory
Center for Biomedical Engineering
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Indian Institute of Technology, Delhi
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2024
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Gaur V, Tyagi W, Das S, Ganguly S, Bhattacharyya J. (2024) CD40 agonist engineered immunosomes modulated tumor microenvironment and showed pro-immunogenic response, reduced toxicity, and tumor free survival in mice bearing glioblastoma. Biomaterials. ;311:122688. doi: 10.1016/j.biomaterials.2024.122688.
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Banerjee A, Singh P, Sheikh PA, Kumar A, Koul V, Bhattacharyya J. (2024). Simultaneous regulation of AGE/RAGE signaling and MMP-9 expression by an immunomodulating hydrogel accelerates healing in diabetic wounds. Biomaterials Advances.:163:213937. https://doi.org/10.1016/j.bioadv.2024.213937
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Banerjee A, Singh P, Sheikh PA, Kumar A, Koul V, Bhattacharyya J. (2024). A multifunctional silk-hyaluronic acid self-healing hydrogel laden with alternatively activated macrophage-derived exosomes reshape microenvironment of diabetic wound and accelerate healing. Int J Biol Macromol. ;270(Pt 2):132384. doi: 10.1016/j.ijbiomac.2024.132384.
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Chakraborty D, Sengupta A, Bhattacharyya J, Jacob. (2024). Facile synthesis and polymerization of 1,4,5-oxadithiepan-2-one for disulfide-based redox-responsive drug delivery. Polymer.;298:126920.https://doi.org/10.1016/j.polymer.2024.126920.
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Pandey M, Bhattacharyya J. (2024) Gut microbiota and epigenetics in colorectal cancer: implications for carcinogenesis and therapeutic intervention. Epigenomics.;16(6):403-418. doi: 10.2217/epi-2023-0382.
2023
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Barnwal, A., Gaur, V., Sengupta, A., Tyagi, W., Das, S., & Bhattacharyya, J. (2023). Tumor Antigen-Primed Dendritic Cell-Derived Exosome Synergizes with Colony Stimulating Factor-1 Receptor Inhibitor by Modulating the Tumor Microenvironment and Systemic Immunity. ACS biomaterials science & engineering, 9(11), 6409–6424. https://doi.org/10.1021/acsbiomaterials.3c00469
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Barnwal A, Ganguly S, Bhattacharyya J*. "A multifaceted nano DEVIL for sustained release of IL-12 to avert the immunosuppressive tumor microenvironment and IL-12 associated toxicities". ACS Applied Materials & Interfaces. 2023
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Barnwal A, Tamang R, Das S, Bhattacharyya J*. “Ponatinib delays the growth of solid tumors by remodeling immunosuppressive tumor-microenvironment through the inhibition of induced PD-L1 expression.” British Journal of Cancer. 2023
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Barnwal A, Das S, Bhattacharyya J. Repurposing Ponatinib as a PD-L1 Inhibitor Revealed by Drug Repurposing Screening and Validation by In Vitro and In Vivo Experiments. ACS Pharmacology & Translational Science. 2023 Jan. doi: 10.1021/acsptsci.2c00214.
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Sharma D, Banerjee A, Bhattacharyya J, Satapathy BK. Structurally stable and surface-textured polylactic acid/copolymer/poly (ε-caprolactone) blend-based electrospun constructs with tunable hydroxyapatite responsiveness. Colloids Surf B Biointerfaces. 2023 Jan;221:112969. doi: 10.1016/j.colsurfb.2022.112969.
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2022
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Barnwal A, Basu B, Tripathi A, Soni N, Mishra D, Banerjee A, Kumar R, Vrati S, and Bhattacharyya J. SARS-CoV-2 spike protein-activated dendritic cell-derived extracellular vesicles induce antiviral immunity in mice. ACS Biomaterials Science & Engineering 2022 8 (12), 5338-5348 doi: 10.1021/acsbiomaterials.2c01094
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Schaal JL, Bhattacharyya J, Brownstein J, et al. Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours. Nature Biomedical Engineering. 2022;6(10):1148-1166. doi:10.1038/s41551-022-00949-4.
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Phour A, Gaur V, Banerjee A, Bhattacharyya J. Recombinant protein polymers as carriers of chemotherapeutic agents. Adv Drug Deliv Rev. 2022;190:114544. doi:10.1016/j.addr.2022.114544.
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Dhingra S, Gaur V, Bhattacharya J, Saha S. Photoinduced micropatterning on biodegradable aliphatic polyester surfaces for anchoring dual brushes and its application in bacteria and cell patterning. J Mater Chem B. 2022;10.1039/d2tb01477g. doi:10.1039/d2tb01477g.
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Sharma D, Dhingra S, Banerjee A, Saha S, Bhattacharyya J, Satapathy BK. Designing suture-proof cell-attachable copolymer-mediated and curcumin- β-cyclodextrin inclusion complex loaded aliphatic polyester-based electrospun antibacterial constructs. Int J Biol Macromol.. 2022 Jul 3:S0141-8130(22)01417-9. doi: 10.1016/j.ijbiomac.2022.06.204.
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​Chawla R, Bhattacharyya J, Moksha L, Phour A, Velpandian T, Kashyap S, Kalyanasundaram D. A novel, minimally invasive implant to assist in repeated intraocular drug delivery. Biomed Microdevices. 2022 May 19;24(2):17. doi: 10.1007/s10544-022-00618-y.
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Dhingra S, Gaur V, Saini V, Rana K, Bhattacharya J, Loho T, Ray S, Bajaj A, Saha S. Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections. Biomater Sci. 2022 Jun 9. doi: 10.1039/d2bm00245k.
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2021
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Joh D. Y, Heggestad J. T, Zhang S, Anderson G. R, Bhattacharyya J et al. Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates. NPJ breast cancer 2021, 7(1), 126. DOI:10.1038/s41523-021-00335-4.
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Banerjee A, Koul V, and Bhattacharyya J *. Fabrication of In Situ Layered Hydrogel Scaffold for the Co-delivery of PGDF-BB/Chlorhexidine to Regulate Proinflammatory Cytokines, Growth Factors, and MMP-9 in a Diabetic Skin Defect Albino Rat Model Biomacromolecules 2021 22 (5), 1885-1900. DOI: 10.1021/acs.biomac.0c01709.
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Banerjee A and Bhattacharyya J. (2021). Current Trends in the Development of Wound Dressings, Biomaterials and Devices.
2020
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Banskota S, Saha S, Bhattacharya J, Kirmani C, Yousefpour C et al. Genetically encoded stealth nanoparticles of a Zwitterionic polypeptide-paclitaxel conjugate have a wider therapeutic window than Abraxane in multiple tumor models. Nano letters 20 (4), 2396-2409
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2017
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Bhattacharyya J, Weitzhandler I, Ho SB, Li X, Liu J, Dewhirst MR and Chilkoti A*. Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy. Advanced Functional Materials. 2017
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Wang J, Bhattacharyya J, Mastria E, Chilkoti A*. A Quantitative Study of the Intracellular Fate of pH-Responsive Doxorubicin-Polypeptide Nanoparticles. Journal of Controlled Release.
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Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W. Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth. Nanoscale. 2017; 9, 34, 12709-12717.
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2016
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Liu J, Pang Y, Bhattacharyya J, Liu W, Weitzhandler I, Li X, and Chilkoti A*. Developing precisely defined drug-loaded nanoparticles by ring-opening polymerization of a paclitaxel prodrug. Advanced Healthcare Materials. 2016; 5, 15, 1868-1673.
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Schaal JL, Li X, Mastria E, Bhattacharyya J, Zalutsky MR, Chilkoti A*, and Liu W*. Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy. Journal of Controlled Release. 2016; 228, 58-66.
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Mukerji R, Schaal JL, Li X, Bhattacharyya J, Asai D, Zalutsky MR, Chilkoti A, Liu W*. Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor. Biomaterials. 2016; 79, 79-87.
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2015
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Bhattacharyya J, Bellucci JJ, Weitzhandler I, McDaniel JR, Spasojevic I, Li X, Lin CC, Chi J-T A, and Chilkoti A*. A Paclitaxel-Loaded Recombinant Polypeptide Nanoparticle Outperforms Abraxane in Multiple Murine Cancer Models. Nature Communications. 2015; 6, 7939. (http://www.newsobserver.com/news/technology/article30031935.html http://bme.duke.edu/news/54320 (http://sites.duke.edu/dukecancerinstitute/?p=4551 (http://issuu.com/dukechronicle/docs/september_16__2015)
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Liu J, Liu W, Weitzhandler I, Bhattacharyya J, Li X, Wang J, Qi Y, Bhattacharjee S and Chilkoti A*. Ring-opening polymerization of prodrugs: A versatile approach to prepare well defined drug-loaded nanoparticles. Angewandte Chemie International Edition. 2015; 54, 3, 1002-1006.
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Bellucci JJ, Bhattacharyya J and Chilkoti A*. A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins. Angewandte Chemie International Edition. 2015; 127, 2, 451-455.
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2014
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Zhao P, Dong S, Bhattacharyya J, Chen M*. iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopicbreast tumors. Molecular Pharmaceutics. 2014; 11, 8, 2703-2712.
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Majumder P, Bhunia S, Bhattacharyya J, and Chaudhuri A*. Inhibiting tumor growth by targeting liposomally encapsulated CDC20siRNA to tumor vasculature: Therapeutic RNA interference. Journal of Controlled Release. 2014; 180, 100-108.
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Mukherjee A, Bhattacharyya J, Sagar MV, and Chaudhuri A*. On the possible involvement of bovine serum albumin precursor in lipofection pathway. Journal of Biosciences. 2014; 39, 1, 43-52.
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2013
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Sinclair SM, Bhattacharyya J, McDaniel JR, Gooden DM, Gopalaswamy R, Chilkoti A, and Setton LA*. A Genetically Engineered Thermally Responsive Sustained-Release Curcumin Depot to treat Neuroinflammation. Journal of Controlled Release. 2013; 171, 1, 38-47.
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Mukherjee A, Bhattacharyya J, Sagar MV, and Chaudhuri A*. Liposomally encapsulated CDC20 siRNA inhibits both solid melanoma tumor growth and spontaneous growth of intravenously injected melanoma cells on mouse lung. Drug Delivery and Translational Research. 2013; 3, 3, 224-234.
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Bellucci JJ, Amiram M, Bhattacharyya J, McCafferty D, and Chilkoti A*.Three-in-One Chromatography-Free Purification, Tag Removal, and Site-Specific Modification of Recombinant Fusion Proteins Using Sortase A and Elastin-like Polypeptides. Angewandte Chemie International Edition. 2013; 52, 13, 3703-3708.
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McDaniel JR, Bhattacharyya J, Vargo KB, Hassouneh W, Hammer DA, and Chilkoti A*. Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation. Angewandte Chemie International Edition. 2013; 52, 6, 1683-1687.
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2009
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Bhattacharyya J, Mondal G, Madhusudhana K, Agawane SB, Ramakrishna S, Gangireddy SR, Madhavi RD, Reddy PK, Konda VR, Rao SR, Udaykumar P, Chaudhuri A*. Single Subcutaneous Administration of RGDK-lipopeptide:rhPDGF-BGene Complex Heals Wounds in Streptozotocin-induced Diabetic Rats. Molecular Pharmaceutics. 2009; 6, 3, 918-927.*** (*** Immediately after its publication, this work received coverage in SciBx, a joint publication of Nature and Biocentury which highlights only 25 research papers each week after scanning thousands of papers published each week across the entire spectrum of life sciences).
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2008
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Mukherjee K, Bhattacharyya J, Sen J, Ramakrishna S and Chaudhuri A. Covalent Grafting of Common Tri-hydroxymethylaminomethane in the Head-group Region Imparts High Serum Compatibility and Mouse Lung Transfection Property to Cationic Amphiphile. Journal of Medicinal Chemistry 2008; 51, 6, 1967–1971. (12)